Fexofenadine is a second-generation antihistamine widely used to treat hay fever (allergic rhinitis) in the UK. It works by blocking the action of histamine, a chemical your body releases during an allergic reaction, helping to relieve symptoms such as sneezing, a runny nose, and itchy or watery eyes.
How to Take Fexofenadine
In the UK, fexofenadine is available in several strengths:
- 120mg tablets — the standard dose for hay fever in adults and children over 12
- 180mg tablets — sometimes prescribed for more severe symptoms or chronic urticaria
- 30mg tablets — used for children aged 6 to 11
The usual dose is one tablet once daily, ideally at the same time each day. Unlike some antihistamines, fexofenadine is best taken with water and not with fruit juice, as grapefruit, orange, and apple juice can reduce its absorption by up to 36%. Always follow the dosing instructions provided by your pharmacist or prescriber.
Availability in the UK
Fexofenadine 120mg became available over the counter in UK pharmacies in 2021 under the brand name Allevia. Previously, it was only available on prescription. Higher doses (180mg) still require a prescription from a GP or can be obtained through online pharmacy services regulated by the MHRA.
Is Fexofenadine Non-Drowsy?
Yes. Fexofenadine is classified as a non-drowsy antihistamine. It does not readily cross the blood-brain barrier, which means it is far less likely to cause sedation than first-generation antihistamines like chlorphenamine (Piriton). Clinical trials show that fexofenadine causes no more drowsiness than a placebo, making it a popular choice for people who need to drive, work, or study during hay fever season.
Who Should Avoid Fexofenadine?
Fexofenadine is generally well tolerated, but it may not be suitable for everyone. Speak to your pharmacist or GP before taking fexofenadine if you:
- Have severe kidney problems
- Are pregnant or breastfeeding — your doctor will weigh the benefits and risks
- Take certain medications, particularly some antacids containing aluminium or magnesium, which can reduce absorption
For most adults, fexofenadine is a safe, effective, and convenient option for managing hay fever throughout the UK pollen season.