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Mounjaro (tirzepatide) is a dual-action injectable that targets both GLP-1 and GIP receptors. It is one of the most effective weight-loss medications available, with clinical trials showing average weight loss of 15–22% of body weight.

Wegovy (semaglutide 2.4mg) is a once-weekly injectable for chronic weight management. It was the first GLP-1 receptor agonist specifically licensed for weight loss in the UK, with trials showing average weight loss of 12–15% of body weight.

Saxenda (liraglutide 3mg) is a daily injectable GLP-1 receptor agonist for weight management. It has a well-established safety profile with over a decade of real-world use. Clinical trials showed average weight loss of 5–10% of body weight.

Orlistat is an oral capsule that blocks the absorption of about one-third of dietary fat. Available as branded Xenical or generic orlistat, it is the only non-injectable prescription weight-loss medication widely available in the UK.